A gene involved in Down syndrome puts the brakes on neurons ...

DSCAM and Dscam are both abbreviations for Down syndrome cell adhesion molecule. In humans, DSCAM refers to a gene that encodes one of several protein ... History/discovery · Gene · Functions · Clinical significance

Down syndrome cell adhesion molecule is conserved in mouse and highly expressed in the adult mouse brain.

Here, we show that DSCAM levels regulate GABAergic synapses formed on neocortical pyramidal neurons (PyNs). In the Ts65Dn mouse model for DS, ...

This gene has 3 transcripts (splice variants), 1 gene allele, 281 orthologues and 36 paralogues. Transcripts. Show ...

DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Human molecular ...

The most significant was DSCAM, a neurological gene expressed widely in the developing brain and in the amygdala and hippocampus of the adult ...

DSCAM (Down syndrome cell adhesion molecule) is a unique neuronal adhesion protein with extensively documented multifaceted functionalities.

The leading DS candidate gene is trisomy of the Down syndrome cell adhesion molecule (DSCAM). This study found that Dscam1 protein is expressed ...

Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same ...